|21 DOSES: One red tablet, once-daily, replenishes iron and more|
|Iron (as Ferrous asparto glycinate [Sumalate®])||75mg||Highly absorbed iron that can be taken with or without food1-8|
|Vitamin C (as Ascorbic acid)||175mg||Pushes iron from GI tract into intestine’s cells9-11|
|Succinic acid||150mg||Helps transport iron from the intestine’s cells into the bloodstream12,13|
|1mg||Fosters red blood cell development with traditional folic acid + a bioactive form that helps some women more2,15-17|
|Vitamin B12 (as Cyanocobalamin)||12mcg||Essential for red blood cell formation2,17|
|Zinc (as Zinc bisglycinate)||10mg||Zinc deficiency often accompanies iron deficiency18,19|
|7 DOSES: To allow cells to regenerate and restore absorption potential, purple tablets are iron-free|
*FeRiva 21/7® contains non-branded L-methylfolate vs. ingredients supplied by branded manufacturers.
The L-methylfolate [(6S)-N5-methyltetrahydrofolic acid calcium salt] in FeRiva 21/7® is less than 1.0% D-isomer.
PRECAUTIONS: Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where Vitamin B12 is deficient. Folic acid in doses above 1.0 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress. While prescribing this nutritional supplement for pregnant women, nursing mothers or for women prior to conception, their medical condition and other drugs, herbs and/or supplements consumption should be considered.
21 days active iron therapy replenishes
iron during the time intestinal cells are most able to absorb iron13,14
7 days iron-free allows cells to regenerate
and replace those blocked from absorbing iron optimally13-15
7 days iron-holiday helps prevent side effects
REFERENCES: 1. FeRiva 21/7™ Prescribing Information, Avion Pharmaceuticals, LLC, 2014. 2. Kamdi SP, Palkar PJ. Efficacy and safety of ferrous asparto glycinate in the management of iron deficiency anaemia in pregnant women. J Obstet Gynaecol. 2014; Early Online: 1–5. doi:10.3109/01443615.2014.930098. Accessed December 29, 2014. 3. Data on File. Avion Pharmaceuticals LLC, Alpharetta, GA. 4. Bovell-Benjamin AC, Viteri FE, and Allen LH. Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status. Am J Clin Nutr. 2000; 71:1563–1569. 5. Pineda O, Ashmead HD, Perez JM, Lemus CP. Effectiveness of iron amino acid chelate on the treatment of iron deficiency anemia in adolescents. J App Nutr. 1994; 46(1,2):2-13. 6. Layrisse M, Garcia- Casal MN, Solano L. Iron bioavailability in humans from breakfasts enriched with iron bis-glycine chelate, phylates and polyphenols. J. Nutr. 2000; 130(9):2195–2199. 7. Iost C, Name JJ, Jeppsen RB, Ashmead HD. Repleting hemoglobin in iron deficiency anemia in young children through liquid milk fortification with bioavailable iron amino acid chelate. J Am Coll Nutr. 1998; 17(2):187-194. 8. Duque X, Martinez H, Vilchis-Gil J, et al. Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: A randomized controlled trial. Nutr J. 2014; 13(71):1-10. doi:10.1186/1475-2891-13-71. Accessed January 5, 2014. 9. Brise H, Hallberg L. Effect of ascorbic acid on iron absorption. Act Med Scan. 1962; 171(suppl 376):51-58. 10. Zijp IM, Korver O, Tijburg LBM. Effect of tea and other dietary factors on iron absorption. Crit Rev Food Sci Nutr. 2000; 40(5):371-398. 11. Lynch SR, Cook JD. Interaction of vitamin C and iron (Abstract). Ann N Y Acad Sci. 1980; 355:32-44. 12. Brise H, Hallberg L. Effect of succinic acid on iron absorption. Acta Med Scand. 1962; 171(suppl 376):59-73. 13. Hallberg L, Norrby A, Solvell L. Oral iron with succinic acid in the treatment of iron deficiency anaemia. Scan J Haematol. 1971; 8:104-111. 14. Zariwala MG, Somavarapu S, Farnaud S, Renshaw D. Comparison study of oral iron preparations using a human intestinal model. Sci Pharm. 2013; 81:1123–1139. 15. Jacobs P, Wormals LA, Gregory MC. Absorption of iron polymaltose and ferrous sulphate in rats and humans. S Afr Med J. 1979; 1065-1072. 16. Devasthali SD, Gordeuk VR, Brittenham GM, Bravo JR, Hughes MA, Keating LJ. Bioavailability of carbonyl iron: A randomized, double-blind study. Eur J Haematol. 1991; 46: 272-278. 17. See, Pineda O. at n. 1, supra. This chart assumes that the Ferrous bisGlycinate Chelate, as indicated, has a bioavailability profile equivalent to Ferrochel®, the subject of Pineda. 18. Norrby A, Solvell L. The absorption of iron during iron therapy. (Abstract volume). XIIIth International Congress of Haematology. J.F. Lehmanns, Munich. 1970; 303. 19. Umar S. Intestinal stem cells. Curr Gastroenterol Rep. 2010; 12(5):340–348.
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